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Preseason
Pre
2
Panthers
1-1
14
@
29
Bills
1-0
Highmark StadiumAug 15, 1:00 PM
Pre
3
Bills
2-0
31
@
7
Browns
0-2
Huntington Bank FieldAug 22, 1:00 PM
Pre
4
Steelers
1-2
27
@
28
Bills
3-0
Highmark StadiumAug 27, 7:00 PM
Regular Season
Week
1
Bills
1-0
36
@
31
Texans
0-1
BUF -1.5 | O/U: 44.5
Reliant StadiumSep 13, 1:00 PM
Week
2
Lions
1-1
31
@
41
Bills
2-0
BUF -4.5 | O/U: 54.5
Highmark StadiumSep 17, 8:15 PM
Week
3
Chargers
0-3
16
@
24
Bills
3-0
BUF -7 | O/U: 50.5
Highmark StadiumSep 27, 1:00 PM
Week
4
Patriots
2-2
29
@
26
Bills
3-1
BUF -7 | O/U: 49.5
Highmark StadiumOct 4, 1:00 PM
Week
5
Bills
4-1
37
@
34
Rams
2-3
LAR -3 | O/U: 54.5
SoFi StadiumOct 12, 8:15 PM
Week
6
Bills
4-1
@
Raiders
3-2
BUF -4.5 | O/U: 53.5
Allegiant StadiumOct 18, 4:25 PM
Week
7
Bye Week
Week
8
Ravens
4-1
@
Bills
4-1
BUF -2.5 | O/U: 51.5
Highmark StadiumNov 1, 1:00 PM
Week
9
Bills
4-1
@
Vikings
5-0
BUF -3 | O/U: 48.5
U.S. Bank StadiumNov 9, 8:15 PM
Week
10
Bills
4-1
@
Jets
2-3
BUF -7 | O/U: 46.5
MetLife StadiumNov 15, 1:00 PM
Week
11
Dolphins
0-5
@
Bills
4-1
BUF -11.5 | O/U: 47.5
Highmark StadiumNov 22, 1:00 PM
Week
12
Chiefs
4-0
@
Bills
4-1
BUF -2.5 | O/U: 50.5
Highmark StadiumNov 26, 8:20 PM
Week
13
Bills
4-1
@
Patriots
3-2
NE -1.5 | O/U: 48.5
Gillette StadiumDec 6, 4:25 PM
Week
14
Bills
4-1
@
Packers
3-2
GB -1.5 | O/U: 49.5
Lambeau FieldDec 13, 8:20 PM
Week
15
Bears
3-2
@
Bills
4-1
BUF -3.5 | O/U: 51.5
Highmark StadiumDec 19, 8:20 PM
Week
16
Bills
4-1
@
Broncos
3-2
BUF -1.5 | O/U: 46.5
Empower Field at Mile HighDec 25, 4:30 PM
Week
17
Bills
4-1
@
Dolphins
0-5
BUF -7.5 | O/U: 47.5
Hard Rock StadiumJan 3, 1:00 PM